Cystic Fibrosis (CF) is a mono-genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Although the disease results in many manifestations, it is consistently characterized by chronic lung infection, poor growth, exocrine pancreatic insufficiency, intestinal obstruction and malabsorption, reduced fertility, and shortened lifespan. Understanding this multi-systemic disease requires the use of animal models that provide the opportunity to study complex physiologic processes in the context of a living organism. As there are a multitude of processes disrupted in CF, animal models that can allow one to approach these processes in a tractable manner are crucial.

Learn more about Cystic Fibrosis from the Cystic Fibrosis Foundation